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KMID : 0811720020060010041
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Korean Journal of Physiology & Pharmacology
2002 Volume.6 No. 1 p.41 ~ p.46
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Renal Tubular Acidosis in Cadmium-Intoxicated Rats
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Yang Saeng Park/Do Whan Ahn
Kyoung Ryong Kim/Jang Kyu Choi/Yang Saeng Park
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Abstract
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Effect of cadmium (Cd) intoxication on renal acid-base regulation was studied in adult male Sprague-Dawley rats. Cd intoxication was induced by subcutaneous injections of CdCl2 at a dose of 2 mg Cd/kg/day for 3∼4 weeks. In Cd-intoxicated animals, arterial pH, PCO2 and plasma bicarbonate concentration decreased, showing a metabolic acidosis. Urine pH and urinary bicarbonate excretion increased and titratable acid excretion decreased with no change in ammonium excretion. In renal cortical brush-border membrane vesicles derived from Cd-exposed animals, the Na+/H+ antiporter activity was significantly attenuated. These results indicate that chronic exposures to Cd impair the proximal tubular mechanism for H+ secretion (i.e., Na+/H+ antiport), leading to a metabolic acidosis.
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KEYWORD
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Cadmium, Kidney, Acid-base,
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